New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Mike and Doug Starn

Focusing on the notion of the double in relation to photography and to Mike and Doug Starn, the authors examine the artists' lives, the development of their work and their use of fragmented and manipulated images. Biographical notes. Circa 84 bibl. ref

Masking and unmasking of photography in post-modernism

Recorded in Ithaca, NY by Cornell University., Sponsored by: Art, Department of., Speaker(s): Grundberg is a visiting artist., Lecture, November 14, 1984.54 minutesGrundberg defines postmodernism and describes its importance.1_b10zrd2z1_0l7g19e